Work

Increasing complexity of the dystrophin-associated protein complex.

Year: 1994

Type: article

Abstract: Duchenne muscular dystrophy is a severe X chromosome-linked, muscle-wasting disease caused by lack of the protein dystrophin. The exact function of dystrophin remains to be determined. However, analysis of its interaction with a large oligomeric protein complex at the sarcolemma and the identification of a structurally related protein, utrophin, is leading to the characterization of candidate genes for other neuromuscular disorders.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.91.18.8307

Authors: J M Tinsley, D J Blake, R A Zuellig, K E Davies

Institutions: John Radcliffe Hospital, University of Oxford

Language: English

Topic: Muscle Physiology and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2072336811

FWCI: 7.431

Cites: 58

Cited by: 191

Related to: 10