Reduced-Intensity Conditioning before Allogeneic Hematopoietic Stem Cell Transplantation in Patients Over 60 Years: A Report from the SFGM-TC
Year: 2011
Type: article
Study design: Observational Study
Abstract: This retrospective multicenter report assessed the outcome of 600 patients with hematologic diseases older than 60 years who received reduced-intensity conditioning (RIC) allogeneic hematopoietic stem cell transplantation (allo-HSCT), with the specific aim to compare outcomes of patients between 60 and 65 years old (N = 493) with those older than 65 years (N = 107). Except for donor age, there were no significant differences between the groups regarding patients, diseases, and allo-HSCT characteristics. At time of RIC allo-HSCT, 276 patients (46%) were in complete remission. With a median follow-up of 22.8 and 23.7 months in the younger and the older groups, respectively, 2-year relapse, nonrelapse mortality, disease-free survival, and overall survival rates were similar in both groups (29.6% vs. 20.4%; 29.9% vs. 34.6%; 40.6% vs. 46.7%; 49.2% vs. 50.2%, respectively; P = NS for all comparisons). In a Cox multivariate analysis, after adjustment for disease and transplant factors, age per se was not an adverse factor for survival (relative risk = 1.08; 95% confidence interval, 0.81-1.44, P = .62). We conclude that in selected patients, RIC allo-HSCT could be offered to patients over 65 years old.
Authors: Patrice Chevallier, Richard M. Szydlo, Didier Blaise, Reza Tabrizi, Mauricette Michallet, Madalina Uzunov, Nathalie Fegueux, François Guilhot, Simona Lapusan, Nicole Gratecos, Jean-Yves Cahn, Gerard Socié, Ibrahim Yakoub-Agha, Anne Huynh, Sylvie Francois, Jacques-Olivier Bay, Sébastien Maury, Agnes Buzyn, Nathalie Contentin, Mohamad Mohty
Institutions: Inserm, Centre Hospitalier Universitaire de Nantes, Centre d'Investigation Clinique de Nantes, Université de Nantes, Nantes Université, Hammersmith Hospital, Imperial College London, Centre de Recherche en Cancérologie de Marseille, Institut Paoli-Calmettes, Université de Bordeaux, Centre Hospitalier Universitaire de Bordeaux, Université Bordeaux Segalen, Hôpital Edouard Herriot, Assistance Publique – Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Hôpital Lapeyronie, Centre Hospitalier Universitaire de Poitiers, Hôtel-Dieu de Paris, Hôpital l'Archet, Hôpital Albert Michallon, Hôpital Saint-Louis, Hôpital Claude Huriez, Hôpital Purpan, Centre Hospitalier Universitaire d'Angers, Centre Hospitalier Universitaire de Clermont-Ferrand, Université Paris-Est Créteil, Centre Hospitalier Universitaire Henri-Mondor, Hôpitaux Universitaires Henri-Mondor, Hôpital Necker-Enfants Malades, Centre Henri Becquerel
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2072447072