Work

Endothelial Dysfunction in Diabetes

Year: 2011

Type: review

Abstract: Type 2 diabetes is characterized by atwo- to fourfold increased risk ofcardiovascular disease. This is gen-erally attributed to the adverse effects of hyperglycemia and oxidative stress on vascular biology. It has also been shown that patients with prediabetic conditions, such as impaired fasting glucose and im-paired glucose tolerance, are at increased risk of cardiovascular disease as well (1). This result suggests that abnormalities in carbohydrate metabolism form a contin-uum that progressively worsens cardio-vascular health; the first step of the adverse sequence of events that leads to the atherosclerotic process is thought to be endothelial dysfunction (2).

Source: Diabetes Care

DOI: 10.2337/dc11-s239

Authors: Angelo Avogaro, Mattia Albiero, Lisa Menegazzo, Saula de Kreutzenberg, Gian Paolo Fadini

Institution: University of Padua

Language: English

Topic: Nitric Oxide and Endothelin Effects

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W2072454523

FWCI: 2.28

Cites: 43

Cited by: 470

Related to: 9