The Association of Growth Hormone Parameters with Skeletal Muscle Phosphocreatine Recovery in Adult Men
Year: 2010
Type: article
Study design: Observational Study
Abstract: CONTEXT: Previous studies have suggested a relationship between GH and mitochondrial function. However, little is known about the relationship of specific GH indices and in vivo measures of mitochondrial function in humans. OBJECTIVE: The objective of this study was to determine the association between GH, IGF-I, and phosphocreatine (PCr) recovery, a measure of mitochondrial function, in otherwise healthy adults. DESIGN: Thirty-seven healthy men and women were studied at a single university medical center. Subjects underwent GH stimulation testing with GH releasing hormone-arginine and measurement of IGF-I. Mitochondrial function was determined by PCr recovery after submaximal exercise by (31)Phosphorous magnetic resonance spectroscopy. Subjects underwent assessment of lean and fat mass with use of dual energy X-ray absorptiometry. RESULTS: There were no differences in PCr recovery between men and women (men 20.7±1.5 vs. women 24.8±1.4 mM/min; P > 0.05). IGF-I (r = 0.33; P = 0.04) was associated with PCr recovery in all subjects. Among men, IGF-I (r = 0.69; P = 0.003), peak stimulated GH (r = 0.52; P = 0.04), and GH area under the curve (AUC) (r = 0.53; P = 0.04) were significantly associated with PCr recovery. However, neither IGF-I, peak stimulated GH, nor GH AUC (all P > 0.05) were associated with PCr recovery in women. After adjusting for age, race, and physical activity, IGF-I remained significantly associated with PCr recovery (β = 0.10; P = 0.02) among men. CONCLUSIONS: IGF-I, peak stimulated GH, and GH AUC are associated with skeletal muscle PCr recovery in men.
DOI: 10.1210/jc.2010-2264
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Massachusetts General Hospital, Harvard Catalyst, Centre d'Imagerie BioMédicale, National Institutes of Health, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston Nutrition Obesity Research Center, Boston University, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources
Awards: G2496518617, Harvard Clinical and Translational Science Center (UL1), Boston Nutrition Obesity Research Center, Growth Hormone, Mitochondria, and Cardio-metabolic Complications of Obesity, Center for Functional Imaging Technologies, G5951230003, Consequences and Treatment of Growth Hormone Deficiency in the Metabolic Syndrome, Strategies to Improve CAD Risk In HIV Disease, Boston Area Nutrition Obesity Research Center (NORC)
OpenAlex ID: W2072590169