Animal foods, protein, calcium and prostate cancer risk: the European Prospective Investigation into Cancer and Nutrition
Year: 2008
Type: article
Study design: Observational Study
Abstract: We examined consumption of animal foods, protein and calcium in relation to risk of prostate cancer among 142 251 men in the European Prospective Investigation into Cancer and Nutrition. Associations were examined using Cox regression, stratified by recruitment centre and adjusted for height, weight, education, marital status and energy intake. After an average of 8.7 years of follow-up, there were 2727 incident cases of prostate cancer, of which 1131 were known to be localised and 541 advanced-stage disease. A high intake of dairy protein was associated with an increased risk, with a hazard ratio for the top versus the bottom fifth of intake of 1.22 (95% confidence interval (CI): 1.07-1.41, P(trend)=0.02). After calibration to allow for measurement error, we estimated that a 35-g day(-1) increase in consumption of dairy protein was associated with an increase in the risk of prostate cancer of 32% (95% CI: 1-72%, P(trend)=0.04). Calcium from dairy products was also positively associated with risk, but not calcium from other foods. The results support the hypothesis that a high intake of protein or calcium from dairy products may increase the risk for prostate cancer.
Source: British Journal of Cancer
Authors: N E Allen, T J Key, P N Appleby, R C Travis, A W Roddam, A Tjønneland, N F Johnsen, K Overvad, J Linseisen, S Rohrmann, H Boeing, T Pischon, H B Bueno-de-Mesquita, L Kiemeney, G Tagliabue, D Palli, P Vineis, R Tumino, A Trichopoulou, C Kassapa, D Trichopoulos, E Ardanaz, N Larrañaga, M-J Tormo, C A González, J R Quirós, M-J Sánchez, S Bingham, K-T Khaw, J Manjer, G Berglund, P Stattin, G Hallmans, N Slimani, P Ferrari, S Rinaldi, E Riboli
Institutions: University of Oxford, Danish Cancer Society, Aarhus University, German Cancer Research Center, German Institute of Human Nutrition, National Institute for Public Health and the Environment, Radboud University Nijmegen, Imperial College London, University of Turin, National and Kapodistrian University of Athens, Hellenic Health Foundation, Instituto de Salud Pública de Navarra, Basque Government, Institut Català d'Oncologia, Gobierno del Principado de Asturias, Andalusian School of Public Health, Medical Research Council, University of Cambridge, Lund University, University Hospital of Umeå, Centre international de recherche sur le cancer
Language: English
Topic: Nutritional Studies and Diet
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,190
Funders: Deutsches Krebsforschungszentrum, Cancer Research UK, National Institute for Health and Care Research, British Heart Foundation, Stroke Association, European Commission, Bundesministerium für Bildung und Forschung, Cancerfonden, Deutsche Krebshilfe, Medical Research Council, World Cancer Research Fund, Instituto de Salud Carlos III
Awards: G2068095830, G484672331, G94526637
OpenAlex ID: W2072605326