Work

Protein kinase C(19–31) pseudosubstrate inhibition of insulin action in rat adipocytes

Year: 1991

Type: article

Abstract: Treatment of intact adipocytes with the autoregulatory PKC pseudosubstrate PKC(19-31) inhibited insulin-stimulated hexose uptake and lipogenesis, with no effect on basal values. The effect was dose-dependent with respective IC50 values of 30 microM and 600 microM for insulin-stimulated hexose uptake in electroporated and intact adipocytes. These studies indicate that PKC may play a role in the mediation of insulin action in adipocytes.

Source: FEBS Letters

DOI: 10.1016/0014-5793(91)80463-d

Authors: Mary L. Standaert, Joachim Sasse, Denise R. Cooper, Robert V. Farese

Institutions: University of South Florida, James A. Haley Veterans' Hospital

Language: English

Topic: Metabolism, Diabetes, and Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Institute of Diabetes and Digestive and Kidney Diseases