Virtual colonoscopy detected colorectal polyps in asymptomatic patients with average risk of colorectal neoplasia
Year: 2004
Type: article
Abstract: Pickhardt PJ, Choi JR, Hwang I, et al . Computed tomographic virtual colonoscopy to screen for colorectal neoplasia in asymptomatic adults. N Engl J Med 2003;349:2191–200. [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Q In asymptomatic patients with average risk for colorectal neoplasia, what is the accuracy of virtual colonoscopy for detecting colorectal polyps? Clinical impact ratings GP/FP/Primary care ★★★★★★☆ IM/Ambulatory care ★★★★★★★ Gastroenterology ★★★★★★★ ### ![Graphic][5] Design: blinded comparison of virtual colonoscopy (VC) with optical colonoscopy (OC). ### ![Graphic][6] Setting: 3 medical centres in the US. ### ![Graphic][7] Patients: 1233 patients (mean age 58 y, 59% men) with average risk of colorectal cancer. Exclusion criteria included positive result on guaiac based test of stool ⩽6 months before referral; iron deficiency anaemia in the previous 6 months; rectal bleeding or haematochezia or unintentional weight loss >4.5 kg in the previous 12 months; OC in the previous 10 years; barium enema in the previous 5 years; history of adenomatous polyps, colorectal cancer, or inflammatory bowel disease; and pregnancy. ### ![Graphic][8] Description of tests: VC was done before OC using a computed tomography (CT) protocol wherein pneumocolon was produced by insufflating room air through a rectal catheter immediately before scanning. A 4 or 8 channel CT scanner (GE LightSpeed or LightSpeed Ultra, General Electric Medical Systems) generated 2 and 3 dimensional (3 D) endoluminal displays of the colon and rectum while the patient held his or her breath in the supine … [1]: {openurl}?query=rft.jtitle%253DN%2BEngl%2BJ%2BMed%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa031618%26rft_id%253Dinfo%253Apmid%252F14657426%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1056/NEJMoa031618&link_type=DOI [3]: /lookup/external-ref?access_num=14657426&link_type=MED&atom=%2Febmed%2F9%2F4%2F123.atom [4]: /lookup/external-ref?access_num=000186921700005&link_type=ISI [5]: /embed/inline-graphic-1.gif [6]: /embed/inline-graphic-2.gif [7]: /embed/inline-graphic-3.gif [8]: /embed/inline-graphic-4.gif
Source: BMJ Evidence-Based Medicine
DOI: 10.1136/ebm.9.4.123
Author: R. H Fletcher
Institution: Harvard University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2072658398