Work

Intracellular Organic Osmolytes: Function and Regulation

Year: 2008

Type: article

Abstract: Cells of almost all organisms accumulate organic osmolytes when exposed to hyperosmolality, most often in the form of high salt or urea. In this review, we discuss 1) how the organic osmolytes protect; 2) the identity of osmolytes in Archaea, bacteria, yeast, plants, marine animals, and mammals; 3) the mechanisms by which they are accumulated; 4) sensors of osmolality; 5) the signaling pathways involved; and 6) mutual counteraction by urea and methylamines.

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.r700042200

Authors: Maurice B. Burg, Joan D. Ferraris

Institutions: National Institutes of Health, National Heart, Lung, and Blood Institute

Language: English

Topic: Bacterial Genetics and Biotechnology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,430

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute