Work

Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90

Year: 2011

Type: article

Abstract: p53 functions as a central node for organizing whether the cell responds to stress with apoptosis or cell cycle arrest; however, the molecular events that lead to apoptotic responses are not completely understood. Here, we identified p90 (also called Coiled-Coil Domain Containing 8) as a unique regulator for p53. p90 has no obvious effects on either the levels of p53 or p53-mediated cell cycle arrest but is specifically required for p53-mediated apoptosis upon DNA damage. Notably, p90 is crucial for Tip60-dependent p53 acetylation at Lys120, therefore facilitating activation of the proapoptotic targets. These studies indicate that p90 is a critical cofactor for p53-mediated apoptosis through promoting Tip60-mediated p53 acetylation.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.1110988108

Authors: Chao Dai, Yi Tang, Sung Yun Jung, Jun Qin, Stuart A. Aaronson, Wei Gu

Institutions: Columbia University, Baylor College of Medicine, Icahn School of Medicine at Mount Sinai

Language: English

Topic: Cancer-related Molecular Pathways

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

Funders: Ellison Medical Foundation, Leukemia and Lymphoma Society, National Institutes of Health, National Cancer Institute

Awards: G1370126020, Regulation of p53 acetylation and deacetylation in tumorigenesis., p53 - Regulators and Effectors, Mechanisms of p53 activation in tumorsuppression