Work

ski can cause selective growth of skeletal muscle in transgenic mice.

Year: 1990

Type: preprint

Abstract: We have created several lines of mice that contain a truncated chicken c-ski cDNA linked to an MSV LTR promoter. Adult mice from three independent lines show large increases in skeletal muscle. All three lines of mice express high levels of c-ski mRNA and protein in skeletal muscle. All other tissues examined show little or no expression of the c-ski transgene. The muscles of one of the three lines were examined in more detail. Type II fast fibers undergo selective hypertrophy in affected muscles of this line.

Source: Genes & Development

DOI: 10.1101/gad.4.9.1462

Authors: P Sutrave, A M Kelly, S H Hughes

Institutions: Frederick National Laboratory for Cancer Research, National Cancer Institute

Language: English

Topic: Muscle Physiology and Disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: U.S. Department of Health and Human Services, National Institutes of Health, National Cancer Institute