Work

69: Therapeutic monitoring of sirolimus is essential in pediatric BMT recipients

Year: 2007

Type: article

Abstract: Limited data on sirolimus (SRL) in adult BMT patients is consistent with a long elimination half-life (t1/2; 57-63 h) and little effect of an occasional missed dose on overall drug exposure. Pharmacokinetic (PK) studies in pediatric organ transplant recipients suggest that SRL may be metabolized more rapidly in children. BMT patients may have variable SRL exposure due to gastrointestinal toxicity, and interactions with calcineurin inhibitors and imidazole antifungaldrugs.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2006.12.072