Year: 2013
Type: article
Study design: Case Report
Abstract: Primary lung clear cell adenocarcinomas represent a very rare histologic type. Little is known about their molecular and clinical features. An asymptomatic 59-year-old female smoker was incidentally diagnosed with a solitary peripheral pulmonary nodule without evidence of lymphadenopathy. The patient underwent a surgical resection. The poorly differentiated adenocarcinoma consisted almost entirely of clear cells (pT1a, G3, R0, pN2, cM0, stage IIIA). Other primary tumors were excluded by immunohistochemistry. Molecular analyses revealed the G12D mutation in the KRAS gene. No EGFR mutation or EML4/ALK fusion gene was present. Clear cell features are sometimes observed in various histologic types of lung cancer. Adenocarcinomas entirely comprised of clear cells are very rare. Here we describe a putative driver mutation in a case of lung clear cell adenocarcinoma. This is the first description of molecular aberrations in a clear cell adenocarcinoma of the lung.
Source: Cancer Treatment Communications
Institution: University Hospital Zurich
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W2072979810