Work

Dry Eye Disease: An Immune-Mediated Ocular Surface Disorder

Year: 2012

Type: article

Abstract: Dry eye disease is a multifactorial disorder of the tears and ocular surface characterized by symptoms of dryness and irritation. Although the pathogenesis of dry eye disease is not fully understood, it is recognized that inflammation has a prominent role in the development and propagation of this debilitating condition. Factors that adversely affect tear film stability and osmolarity can induce ocular surface damage and initiate an inflammatory cascade that generates innate and adaptive immune responses. These immunoinflammatory responses lead to further ocular surface damage and the development of a self-perpetuating inflammatory cycle. Herein, we review the fundamental links between inflammation and dry eye disease and discuss the clinical implications of inflammation in disease management.

Source: Archives of Ophthalmology

DOI: 10.1001/archophthalmol.2011.364

Authors: William Stevenson, Sunil K Chauhan, Reza Dana

Institutions: Massachusetts Eye and Ear Infirmary, Harvard University

Language: English

Topic: Ocular Surface and Contact Lens

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Eye Institute