Work

CTCF-dependent chromatin insulator as a built-in attenuator of angiogenesis

Year: 2012

Type: article

Abstract: VEGF is a pivotal pro-angiogenic growth factor and its dosage decisively impacts vascularization. We recently identified a CTCF-dependent chromatin insulator that critically restrains the transcriptional induction of VEGF and angiogenesis. We postulate that CTCF may exert enhancer blocking by mediating chromatin looping and/or RNA polymerase pausing at the VEGF locus.

Source: Transcription

DOI: 10.4161/trns.19634

Authors: Jianrong Lu, Ming Tang

Institutions: University of Florida Health, University of Florida

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Cancer Institute