Work

Rational Design of Amyloid Binding Agents Based on the Molecular Rotor Motif

Year: 2009

Type: article

Abstract: New fluorescent probes, designed based on the molecular rotor motif, displayed good affinity for aggregated β-amyloid peptides. The physical and fluorescence properties of these probes can be fine tuned by modifying their chemical structures. These findings suggest that the general motif of molecular rotors can lead to the design of new diagnostic tools for amyloid imaging in Alzheimer's disease and related neurodegenerative conditions.

Source: ChemMedChem

DOI: 10.1002/cmdc.200900440

Authors: Jeyanthy Sutharsan, Marianna Dakanali, Christina C. Capule, Mark A. Haidekker, Jerry Yang, Emmanuel A. Theodorakis

Institutions: University of California San Diego, University of Georgia

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Science Foundation, Wallace H. Coulter Foundation, National Institute on Aging, National Center for Research Resources