Year: 2013
Type: article
Study design: Observational Study
Abstract: Selenium is an essential trace element and circulating selenium concentrations have been associated with a wide range of diseases. Candidate gene studies suggest that circulating selenium concentrations may be impacted by genetic variation; however, no study has comprehensively investigated this hypothesis. Therefore, we conducted a two-stage genome-wide association study to identify genetic variants associated with serum selenium concentrations in 1203 European descents from two cohorts: the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening and the Women's Health Initiative (WHI). We tested association between 2,474,333 single nucleotide polymorphisms (SNPs) and serum selenium concentrations using linear regression models. In the first stage (PLCO) 41 SNPs clustered in 15 regions had p < 1 × 10(-5). None of these 41 SNPs reached the significant threshold (p = 0.05/15 regions = 0.003) in the second stage (WHI). Three SNPs had p < 0.05 in the second stage (rs1395479 and rs1506807 in 4q34.3/AGA-NEIL3; and rs891684 in 17q24.3/SLC39A11) and had p between 2.62 × 10(-7) and 4.04 × 10(-7) in the combined analysis (PLCO + WHI). Additional studies are needed to replicate these findings. Identification of genetic variation that impacts selenium concentrations may contribute to a better understanding of which genes regulate circulating selenium concentrations.
Source: Nutrients
DOI: 10.3390/nu5051706
Institutions: Fred Hutch Cancer Center, University of Washington, University of New Mexico, University of Copenhagen, Translational Genomics Research Institute, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Memorial Hospital of Rhode Island, Roswell Park Comprehensive Cancer Center
Language: English
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,499
Awards: G109231058, G1107292973, Women's Health Initiative, Women's Health Initiative, G156924709, Women's Health Initiative, G1593340546, G1617453120, G1646017446, G206718646, Women's Health Initiative, Colon Cancer Prevention with Selenium, G2253702613, G2295046671, G2417273319, G2547046739, G257474614, G2852769941, G2880260212, Prospective Study on Selenium, Genectics of Selenoenzymes, and Colorectal Cancer, Women's Health Initiative Memory Study (WHIMS), G3544793024, Women's Health Initiative, G3642616392, Women's Health Initiative, Women's Health Initiative, G413560588, G4214622172, G4216744017, G4281851297, COORDINATING CENTER FOR WOMEN'S HEALTH INITIATIVE, G429396632, G4321061599, G445374210, G4454202622, G4503763930, G4560602636, Genome Wide Association Coordinating Center, G4580544488, G484043965, G4940723635, G5183277930, FOR ALL FIELD CENTER FOR WHI EXTENSION, G530368906, G532295152, G555506801, JH/CIDR Genotyping for Genome-Wide Association Studies, G603760282, G6464247198, G6670851527, Women's Health Initiative, G7066869570, G7071300326, G7223985928, G7272550893, Women's Health Initiative, G7323080267, G7651777114, G8780700017, G8934942062, G9000002220, G9000015938, G9000016408, G9000029166, G9000072420, G9000099044, G9000151586, G9000284018, Genome-Wide Association Studies, G999174792
OpenAlex ID: W2073491711