Work

Applying the ResFinder and VirulenceFinder web-services for easy identification of acquired antibiotic resistance andE. colivirulence genes in bacteriophage and prophage nucleotide sequences

Year: 2014

Type: article

Abstract: Extensive research is currently being conducted on the use of bacteriophages for applications in human medicine, agriculture and food manufacturing. However, phages are important vehicles of horisontal gene transfer and play a significant role in bacterial evolution. As a result, concern has been raised that this increased use and dissemination of phages could result in spread of deleterious genes, e.g., antibiotic resistance and virulence genes. Meanwhile, in the wake of the genomic era, several tools have been developed for characterization of bacterial genomes. Here we describe how two of these tools, ResFinder and VirulenceFinder, can be used to identify acquired antibiotic resistance and virulence genes in phage genomes of interest. The general applicability of the tools is demonstrated on data sets of 1,642 phage genomes and 1,442 predicted prophages.

Source: Bacteriophage

DOI: 10.4161/bact.27943

Authors: Kortine Annina Kleinheinz, Katrine Grimstrup Joensen, Mette Voldby Larsen

Institutions: Technical University of Denmark, Statens Serum Institut

Language: English

Topic: Bacteriophages and microbial interactions

Subfield: Ecology

Field: Environmental Science

Domain: Physical Sciences

Open Access status: bronze

Funders: Center for Genomic Epidemiology, Danmarks Tekniske Universitet

OpenAlex ID: W2073518110

FWCI: 10.34

Cites: 44

Cited by: 323

Related to: 10