Work

Chromosomal localization of human leukocyte, fibroblast, and immune interferon genes by means of in situ hybridization

Year: 1982

Type: article

Abstract: Recombinant plasmids containing cDNA inserts from human leukocyte interferon (IFN-alpha), fibroblast interferon (IFN-beta), or immune interferon (INF-gamma) genes were radiolabeled and hybridized in situ to human metaphase chromosome preparations. The results localized the human IFN-alpha and IFN-beta genes to the short arm of chromosome 9(p21-->pter) and localized the IFN-gamma gene to the long arm of chromosome 12(q24.1).

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.79.24.7809

Authors: Jeffrey M. Trent, Sharon Olson, Richard M. Lawn

Institutions: University of Arizona, Genentech

Language: English

Topic: interferon and immune responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2073693170

FWCI: 7.54

Cites: 35

Cited by: 188

Related to: 10