Work

259. Plasmid DNA Encoding the Anti-Inflammatory Cytokine Gene, Interleukin-10 (IL-10) for Chronic Pain Control: Taking Advantage of Nuclear Scaffold/Matrix Attachment Regions

Year: 2006

Type: article

Abstract: Chronic pathological pain is a major unresolved clinical problem. Spinal cord glial cells are important in diverse forms of enhanced pain states via their release of proinflammatory cytokines. Interleukin-10 (IL-10), a potent anti-inflammatory cytokine, suppresses proinflammatory cytokine production & activity. We have shown that spinal delivery (intrathecal; i.t.) of IL-10 protein resolves animal models of pathological pain. Both i.t. IL-10 protein or i.t. viral vector-delivered IL-10 gene lead to transient therapeutic effects (2hr & 2 wk, respectively).

Source: Molecular Therapy

DOI: 10.1016/j.ymthe.2006.08.286