Work

Regioselective Synthesis of Benzimidazolones via Cascade C–N Coupling of Monosubstituted Ureas

Year: 2014

Type: article

Abstract: A direct method for the regioselective construction of benzimidazolones is reported wherein a single palladium catalyst is employed to couple monosubstituted urea substrates with differentially substituted 1,2-dihaloaromatic systems. In this method, the catalyst is able to promote a cascade of two discrete chemoselective C-N bond-forming processes that allows the highly selective and predictable formation of complex heterocycles from simple, readily available starting materials.

Source: Organic Letters

DOI: 10.1021/ol501531q

Authors: Johannes B. Ernst, Nicholas E. S. Tay, Nathan T. Jui, Stephen L. Buchwald

Institution: Massachusetts Institute of Technology

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: Amgen, National Institutes of Health, National Institute of General Medical Sciences