Work

Electrophilic Aromatic Selenylation: New OPRT Inhibitors

Year: 2010

Type: article

Abstract: 2-Ethoxyethaneseleninic acid reacts with electron-rich aromatic substrates to deliver, by way of the selenoxides, the (2-ethoxyethyl)seleno ethers, which can in turn be transformed into a diverse set of aryl-selenylated products. Among these, a family of 5-uridinyl derivatives shows submicromolar inhibition of human and malarial orotate phosphoribosyltransferase.

Source: Organic Letters

DOI: 10.1021/ol1010032

Authors: Mohannad Abdo, Yong Zhang, Vern L. Schramm, Spencer Knapp

Institutions: Rutgers, The State University of New Jersey, Albert Einstein College of Medicine

Language: English

Topic: Organoselenium and organotellurium chemistry

Subfield: Toxicology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: green

Funders: National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases

Awards: Transition State Analysis of Enzymatic Reactions, Transition State Analysis of Enzymatic Reactions, G5016933685, G521541070, G5636258499