Year: 2014
Type: editorial
Abstract: Neurodegenerative diseases as diverse as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, stroke, and depression are thought to share a common pathogenesis mechanism-the aggregation and deposition of misfolded proteins, which leads to progressive central nervous system impairments.This special issue compiled 11 articles, most of which are novel and excellent investigations in this field.Two modalities of neuroimaging techniques (PET and MRS) are leading to a greater understanding of quantification for the early and differential diagnosis of Alzheimer's disease.P. Daniela et al. conducted a meta-analysis and GRADE analysis reporting differences in the levels of sensitivity and specificity for the standard visual FDG PET scan or dichotomous readout based amyloid PET with respect to parametric or semiquantitative analysis.The review by Radoslaw Magierski and Tomasz Sobow summarized the main results obtained from the application of neuroimaging techniques in Dementia with Lewy bodies (DLB) cases, mainly focusing on proton magnetic resonance spectroscopy (1H-MRS).DLB and Parkinson's disease share clinical symptoms and neuropsychological profiles.Proton magnetic resonance spectroscopy (1H-MRS) provides a noninvasive method of assessing an in vivo biochemistry of brain tissue.
Source: BioMed Research International
DOI: 10.1155/2014/419317
Institutions: Xi'an Jiaotong University, Capital Medical University, Beijing Tian Tan Hospital, University of Florida, Beijing Normal University, State Key Laboratory of Cognitive Neuroscience and Learning, University of Maryland, Baltimore, University of Hong Kong, Chengdu University of Traditional Chinese Medicine
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,680
OpenAlex ID: W2074341690