Work

Novel Strategy to Enhance NK Cell Activity

Year: 2015

Type: article

Abstract: Novel therapeutic approaches are urgently needed for many malignancies such as Acute Myeloid Leukemia (AML). We have developed a new therapeutic strategy based upon NK cell immunotherapy that exhibits high clinical potential based upon cell and animal studies. While the harnessing of NK cells for cellular therapy against malignancies has been a topic of interest for several decades, our approach overcomes a major hurdle of insufficient NK cell cytotoxic activity. We have identified that targeting the kinase GSK3 through pharmacologic and genetic approaches leads to the hyperactivation of human blood derived NK cells and a significant improvement in efficacy as compared to traditionally used activated NK cells or chemotherapy in our mouse AML model systems.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2014.11.213

Authors: David Wald, Reshmi Parameswaran, Stephen Moreton, Marcos J.G. de Lima, Dean Lee, Paramaeswaran Ramakrishnan

Institutions: Case Western Reserve University, University Hospitals Seidman Cancer Center, The University of Texas MD Anderson Cancer Center

Language: English

Topic: Immune Cell Function and Interaction

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650