Year: 2002
Type: article
Abstract: Exact methods are available for the simulation of isothermal, well-mixed stochastic chemical kinetics. As increasingly complex physical systems are modeled, however, these methods become difficult to solve because the computational burden scales with the number of reaction events. This paper addresses one aspect of this problem: the case in which reacting species fluctuate by different orders of magnitude. By partitioning the system into subsets of “fast” and “slow” reactions, it is possible to bound the computational load by approximating “fast” reactions either deterministically or as Langevin equations. This paper provides a theoretical background for such approximations and outlines strategies for computing these approximations. Two motivating examples drawn from the fields of particle technology and biotechnology illustrate the accuracy and computational efficiency of these approximations.
Source: The Journal of Chemical Physics
DOI: 10.1063/1.1505860
Authors: Eric L. Haseltine, James B. Rawlings
Institution: University of Wisconsin–Madison
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Funder: National Science Foundation
OpenAlex ID: W2074401358