Work

Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate

Year: 2013

Type: article

Abstract: The investigation of metabolic pathways disturbed in isocitrate dehydrogenase (IDH) mutant tumors revealed that the hallmark metabolic alteration is the production of D-2-hydroxyglutarate (D-2HG). The biological impact of D-2HG strongly suggests that high levels of this metabolite may play a central role in propagating downstream the effects of mutant IDH, leading to malignant transformation of cells. Hence, D-2HG may be an ideal biomarker for both diagnosing and monitoring treatment response targeting IDH mutations. Magnetic resonance spectroscopy (MRS) is well suited to the task of noninvasive D-2HG detection, and there has been much interest in developing such methods. Here, we review recent efforts to translate methodology using MRS to reliably measure in vivo D-2HG into clinical research.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci67229

Authors: Ovidiu C. Andronesi, Otto Rapalino, Elizabeth Gerstner, Andrew Chi, Tracy T. Batchelor, Dan P. Cahill, A. Gregory Sorensen, Bruce R. Rosen

Institutions: Harvard University, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Siemens Healthcare (United States)

Language: English

Topic: Advanced MRI Techniques and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Massachusetts General Hospital, Harvard Catalyst, Centre d'Imagerie BioMédicale, National Institutes of Health, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, National Cancer Institute, National Center for Research Resources

Awards: G1220546045, SPECTROSCOPY/IMAGING CONSOLE FOR STUDIES AT 94 TESLA, G2268713923, G338756917, G3549079774, Clinical and Molecular Studies of Malignant Brain Tumors, G653110949, Quantify treatment response in IDH1 mutant glioma patients with metabolic MRI, G7499259106, A Siemens MAGNETOTOM Trio 3 Tesla MRI System, A Storage Area Network for Structural and Functional Image Analysis, G8998766674, G9000037461, G9000041374, G9000165426, Training Program in Nervous System Tumors, G953382460, G979501398

OpenAlex ID: W2074448607

FWCI: 12.82

Cites: 60

Cited by: 171

Related to: 10