Work

Structural analysis of the regulatory region of the human corticotropin releasing hormone gene

Year: 1990

Type: article

Abstract: A DNA fragment containing the human corticotropin releasing hormone (CRH) gene, along with 9 kb of upstream and 4 kb of downstream sequences, was isolated from a human genomic DNA library. Nucleotide sequence analysis of the proximal 918 nucleotides 5' flanking the putative major mRNA start site of the human gene and comparison to the 866 nucleotide long homologous ovine sequence, revealed that this region of the CRH gene consists of two distinct areas with different degrees of homology, varying from 72% to 94%. The putative functional features of the human sequence were identified. Many, but not all, features were conserved in the ovine sequence. The highly conserved nature of the regulatory region of this gene makes it a good candidate for tracing possible related genetic defects of the hypothalamic-pituitary-adrenal (HPA) axis.

Source: FEBS Letters

DOI: 10.1016/0014-5793(90)80272-k

Authors: Nikos C. Vamvakopoulos, Michael Karl, Vanessa Mayol, Teresa Gomez, Constantine A. Stratakis, Andrew Margioris, George P. Chrousos

Institutions: National Institutes of Health, National Centre of Scientific Research "Demokritos", Eunice Kennedy Shriver National Institute of Child Health and Human Development

Language: English

Topic: Stress Responses and Cortisol

Subfield: Behavioral Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2074483761

FWCI: 1.57

Cites: 38

Cited by: 42

Related to: 10