Work

Deletion of U L 21 Causes a Delay in the Early Stages of the Herpes Simplex Virus 1 Replication Cycle

Year: 2012

Type: article

Abstract: The herpes simplex virus 1 (HSV-1) U(L)21 gene encodes a 62-kDa tegument protein with homologs in the alpha-, beta-, and gammaherpesvirus subfamilies. In the present study, we characterized a novel U(L)21-null virus and its genetic repair to determine whether this protein plays a role in early stages of the HSV-1 replication cycle. Single-step growth analyses, protein synthesis time courses, and mRNA quantifications indicated that the absence of U(L)21 results in a delay early in the HSV-1 replication cycle.

Source: Journal of Virology

DOI: 10.1128/jvi.00411-12

Authors: Ekaette F. Mbong, Lucille Woodley, Elizabeth Frost, Joel D. Baines, Carol Duffy

Institutions: University of Alabama, Cornell University

Language: English

Topic: Herpesvirus Infections and Treatments

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Howard Hughes Medical Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases