Work

Cotinine replacement levels for a 21 mg/day transdermal nicotine patch in an outpatient treatment setting

Year: 1999

Type: article

Abstract: This study examined plasma cotinine replacement levels of 56 outpatient smokers administered a 21 mg/day transdermal nicotine patch (Nicoderm CQ ). The percentage of cotinine replacement ranged from 35 to 232% (mean 107%; median 90.5%). Four subject variables were found to be significantly correlated with percentage of cotinine replacement-baseline cotinine level, prior quit attempts, gender, and the Fagerström Tolerance Questionnaire score. A two-variable model consisting of baseline cotinine level and gender provided the most powerful predictor combination. The percentage of cotinine replacement was not predictive of post-treatment smoking. The relatively high levels of cotinine replacement obtained using the Nicoderm CQ 21 mg/day patch suggest cautious use of higher dose treatment with this particular patch.

Source: Drug and Alcohol Dependence

DOI: 10.1016/s0376-8716(98)00163-x

Authors: Peter Gariti, Arthur I. Alterman, Wayne Barber, Navjyot Bedi, Gary Luck, Avital Cnaan

Institutions: Philadelphia VA Medical Center, University of Pennsylvania

Language: English

Topic: Smoking Behavior and Cessation

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,380