Year: 2011
Type: review
Abstract: Effective screening for major aneuploidies can be provided in the first trimester of pregnancy. Screening by a combination of fetal nuchal translucency and maternal serum free-β-human chorionic gonadotrophin and pregnancy-associated plasma protein-A can identify about 90% of fetuses with trisomy 21 and other major aneuploidies for a false-positive rate of 5%. Improvement in the performance of first-trimester screening can be achieved by firstly, inclusion in the ultrasound examination assessment of the nasal bone and flow in the ductus venosus, hepatic artery and across the tricuspid valve, and secondly, carrying out the biochemical test at 9 to 10 weeks and the ultrasound scan at 12 weeks.
Source: Prenatal Diagnosis
DOI: 10.1002/pd.2637
Author: Kypros H. Nicolaides
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funder: Fetal Medicine Foundation
Awards: G1300008475, G363604241
OpenAlex ID: W2074678889