Work

TMEM106B risk variant is implicated in the pathologic presentation of Alzheimer disease

Year: 2012

Type: article

Abstract: TDP-43 protein is the major component of the ubiquitin-positive inclusions in neurons and glia of patients with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP).[1][1] TDP-43 pathology has also been detected in as many as 56% of patients with Alzheimer disease (AD

Source: Neurology

DOI: 10.1212/wnl.0b013e318264e3ac

Authors: Nicola J. Rutherford, Minerva M. Carrasquillo, Ma Li, Gina Bisceglio, Joshua Menke, Keith A. Josephs, Joseph E. Parisi, Ronald C. Petersen, Neill R. Graff-Radford, Steven G. Younkin, Dennis W. Dickson, Rosa Rademakers

Institutions: Mayo Clinic, Mayo Clinic in Florida

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Dana Foundation, Pfizer, CurePSP, Elan, National Institutes of Health, Forest Laboratories, National Institute on Aging, National Institute of Neurological Disorders and Stroke, State of Florida

Awards: Einstein Aging Study, Progranulin: Mutation and Regulation in Neurodegenerative disease, Understanding the role of TDP-43 in Alzheimer’s disease and FTLD, Progranulin, TDP-43 and Cell Death, G9000281426, Mayo Alzheimer's Disease Research Center

OpenAlex ID: W2074712798

FWCI: 4.893

Cites: 7

Cited by: 97

Related to: 10