Comment: Analyses Using Time-Dependent Pioglitazone Usage in Cox Models May Lead to Wrong Conclusions About Its Association With Cancer
Year: 2011
Type: letter
Abstract: We read the two articles published in a recent issue of Diabetes Care by Lewis et al. (1) and Ferrara et al. (2) with interest. The first study tested a time-dependent use of pioglitazone for the risk of bladder cancer among 193,099 diabetic patients in the Kaiser Permanente Northern California Diabetes Registry and concluded that use of the drug over 24 months was associated with an increased risk of bladder cancer (hazard ratio 1.4, 95% CI 1.03–2.0). The second study tested a time-dependent use of pioglitazone for the risk of cancer among 252,467 diabetic patients aged ≥40 years from the Kaiser Permanente Northern California Diabetes Registry and found that ever use of pioglitazone was not …
Source: Diabetes Care
DOI: 10.2337/dc11-0627
Authors: Xilin Yang, Juliana C.N. Chan
Institution: Chinese University of Hong Kong
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W2074784078