Work

A time to reap, a time to sow: Mitophagy and biogenesis in cardiac pathophysiology

Year: 2014

Type: review

Abstract: Balancing mitophagy and mitochondrial biogenesis is essential for maintaining a healthy population of mitochondria and cellular homeostasis. Coordinated interplay between these two forces that govern mitochondrial turnover plays an important role as an adaptive response against various cellular stresses that can compromise cell survival. Failure to maintain the critical balance between mitophagy and mitochondrial biogenesis or homeostatic turnover of mitochondria results in a population of dysfunctional mitochondria that contribute to various disease processes. In this review we outline the mechanics and relationships between mitophagy and mitochondrial biogenesis, and discuss the implications of a disrupted balance between these two forces, with an emphasis on cardiac physiology. This article is part of a Special Issue entitled "Mitochondria: From Basic Mitochondrial Biology to Cardiovascular Disease".

Source: Journal of Molecular and Cellular Cardiology

DOI: 10.1016/j.yjmcc.2014.10.003

Authors: Allen M. Andres, Aleksandr Stotland, Bruno B. Queliconi, Roberta A. Gottlieb

Institution: Cedars-Sinai Smidt Heart Institute

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,120