Work

Remarkable facilitation of hetero-cycloisomerizations with water and other polar protic solvents: metal-free synthesis of indolizines

Year: 2010

Type: article

Abstract: Hetero-cycloisomerization reactions of propargylic alcohol derivatives leading to indolizines have been demonstrated to proceed in the presence of water alone. This stands as a significant advance over the previous methods using Pt, Cu or Ag salts paired with ligands in organic solvents such as benzene, acetonitrile or methylene chloride.

Source: Green Chemistry

DOI: 10.1039/c0gc00198h

Authors: Alison R. Hardin Narayan, Richmond Sarpong

Institution: University of California, Berkeley

Language: English

Topic: Synthesis and Reactivity of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: G5074174441