Work

Advances in Aspergillus secondary metabolite research in the post-genomic era

Year: 2012

Type: review

Abstract: This review studies the impact of whole genome sequencing on Aspergillus secondary metabolite research. There has been a proliferation of many new, intriguing discoveries since sequencing data became widely available. What is more, the genomes disclosed the surprising finding that there are many more secondary metabolite biosynthetic pathways than laboratory research had suggested. Activating these pathways has been met with some success, but many more dormant genes remain to be awakened.

Source: Natural Product Reports

DOI: 10.1039/c2np00084a

Authors: James F. Sanchez, Amber D. Somoza, Nancy P. Keller, Clay C. C. Wang

Institutions: University of Southern California, University of Wisconsin–Madison

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Applied Microbiology and Biotechnology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: green

Funders: National Institute for Health and Care Research, National Institutes of Health, University of California, Irvine, National Institute of General Medical Sciences

Award: Mining the Aspergillus nidulans Secondary Metabolome