Work

Motor unit number estimation in infants and children with spinal muscular atrophy

Year: 2002

Type: article

Abstract: Spinal muscular atrophy (SMA) is a disease of lower motor neurons. Motor unit number estimation (MUNE) is an electrophysiologic method to estimate the number of motor neurons innervating a muscle group. We applied the multiple point stimulation technique to the ulnar nerve--hypothenar muscle group to study lower motor neuron loss in 14 SMA subjects, including those presymptomatic, and varying from newborn through 45 years of age. Preliminary data support the value of MUNE to help understand the time course of motor neuron loss in SMA.

Source: Muscle & Nerve

DOI: 10.1002/mus.10050

Authors: Mark B. Bromberg, Kathryn J. Swoboda

Language: English

Topic: Neurogenetic and Muscular Disorders Research

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Neurological Disorders and Stroke, National Center for Research Resources, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: University of Utah Center for Clinical and Translational Science-UL1, Therapeutic Opportunities in Spinal Muscular Atrophy, The Electrophysiology of Motor Neuron Diseases, G6465023974