Work

Direct Alkylation of Heteroaryls Using Potassium Alkyl- and Alkoxymethyltrifluoroborates

Year: 2011

Type: article

Abstract: A direct alkylation of various heteroaryls using stoichiometric potassium alkyl- and alkoxymethyltrifluoroborates has been developed. This method leads to the synthesis of complex substituted heterocycles, which have been obtained with yields up to 89%.

Source: Organic Letters

DOI: 10.1021/ol2003572

Authors: Gary A. Molander, Virginie Colombel, Valerie A. Braz

Institution: University of Pennsylvania

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institute of General Medical Sciences, National Center for Research Resources

Awards: Agilent 5973 GC/MS System, Organotrifluoroborates in Selective Organic Synthesis