Work

Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes

Year: 2009

Type: article

Abstract: Fibroblast growth factor 21 (FGF21) has beneficial effects of improving the plasma glucose and lipid profiles in diabetic rodents. Here, we investigated carbohydrate response element binding protein (ChREBP) involvement in the regulation of FGF21 mRNA expression in liver. Glucose stimulation and adenoviral overexpression of dominant active ChREBP increased FGF21 mRNA. Consistently, adenoviral expression of dominant negative Mlx inhibited glucose induction of FGF21 mRNA. Furthermore, deletion studies of mouse FGF21 gene promoter (-2000 to +65 bp) revealed a glucose responsive region between -74 and -52 bp. These findings suggest that FGF21 expression is regulated by ChREBP.

Source: FEBS Letters

DOI: 10.1016/j.febslet.2009.07.053

Authors: Katsumi Iizuka, Jun Takeda, Yukio Horikawa

Institutions: Gunma University, Gifu University, Institute for Molecular and Cellular Regulation, Gunma University

Language: English

Topic: Fibroblast Growth Factor Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Ono Medical Research Foundation, Japan Society for the Promotion of Science