Association of T Cell Proliferative Responses and Phenotype with Virus Control in Chronic Progressive HIV‐1 Disease
Year: 2004
Type: article
Abstract: The role of T cell immunity in virus control during chronic infection was examined in 79 human immunodeficiency virus type 1 (HIV-1)-infected subjects randomized to receive antiretroviral therapy. HIV-1 p24-specific responses were detected in 20% of the subjects at baseline, increasing to 28% of the subjects at weeks 16-24. Induction of virologic suppression was associated with lower plasma HIV-1 RNA levels and a higher percentage of Fas+ CD8+ T cells at baseline, whereas maintenance of suppression was associated with higher CD4+ T cell counts and, marginally, with a higher percentage of Fas+ CD4+ T cells at weeks 16-24. These findings indicate that Fas coexpression on T cells, in addition to plasma HIV-1 RNA levels and CD4+ T cell counts, may predict virologic outcome.
DOI: 10.1086/381038
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
Awards: G1289108059, G1621430908, G1976846336, G2239548760, STATISTICAL AND DATA MANAGEMENT CENTER, IMMUNOLOGY AND MOLECULAR VIROLOGY OF ACUTE HIV INFECTION, G687681150, University of Washington/Fred Hutch Center for AIDS Research, MIAMI ADULT AIDS CLINICAL TRIALS GROUP, AACTG, ADULT AIDS CLINICAL TRIALS UNIT, G986646304
OpenAlex ID: W2075512595