Work

Apoptotic Death of Cancer Stem Cells for Cancer Therapy

Year: 2014

Type: review

Abstract: Cancer stem cells (CSCs) play crucial roles in tumor progression, chemo- and radiotherapy resistance, and recurrence. Recent studies on CSCs have advanced understanding of molecular oncology and development of novel therapeutic strategies. This review article updates the hypothesis and paradigm of CSCs with a focus on major signaling pathways and effectors that regulate CSC apoptosis. Selective CSC apoptotic inducers are introduced and their therapeutic potentials are discussed. These include synthetic and natural compounds, antibodies and recombinant proteins, and oligonucleotides.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms15058335

Authors: Ying-Chun He, Fang-Liang Zhou, Yi Shen, Duan-Fang Liao, Deliang Cao

Institutions: Hunan University of Traditional Chinese Medicine, SIU Medicine

Language: English

Topic: Cancer Cells and Metastasis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,499