Work

Role of 3‐O‐sulfated heparan sulfate in virus‐induced polykaryocyte formation

Year: 2007

Type: article

Abstract: One way herpes simplex virus type-1 (HSV-1) spreads in vivo is by polykaryocytes formation. Here we demonstrate that polykaryocyte production during HSV-1 spread in cultured human corneal fibroblasts (CF) required heparan sulfate (HS) and more specifically 3-O sulfated HS (3-OS HS). The polykaryocyte formation heavily depended on the expression of HS on target (CF) cells but not on glycoprotein expressing effector cells. Furthermore, we provide the first visual evidence of 3-OS HS and HSV-1 gD colocalization during the membrane fusion process. Taken together our results provide novel insight into the significance of HS in polykaryocyte formation.

Source: FEBS Letters

DOI: 10.1016/j.febslet.2007.08.029

Authors: Vaibhav Tiwari, Gerdy B. ten Dam, Beatrice Y.J.T. Yue, Toin H. van Kuppevelt, Deepak Shukla

Institutions: University of Illinois Chicago, Radboud University Medical Center

Language: English

Topic: Herpesvirus Infections and Treatments

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Illinois Society for the Prevention of Blindness, U.S. Public Health Service, National Eye Institute, National Institute of Allergy and Infectious Diseases