Work

Patterning nanowire and micro-/nanoparticle array on micropillar-structured surface: Experiment and modeling

Year: 2010

Type: article

Abstract: DNA molecules in a solution can be immobilized and stretched into a highly ordered array on a solid surface containing micropillars by molecular combing technique. However, the mechanism of this process is not well understood. In this study, we demonstrated the generation of DNA nanostrand array with linear, zigzag, and fork-zigzag patterns and the microfluidic processes are modeled based on a deforming body-fitted grid approach. The simulation results provide insights for explaining the stretching, immobilizing, and patterning of DNA molecules observed in the experiments.

Source: Biomicrofluidics

DOI: 10.1063/1.3474639

Authors: Chung Hsun Lin, Jingjiao Guan, Shiu Wu Chau, Shia Chung Chen, L. James Lee

Institutions: Florida State University, Florida A&M University - Florida State University College of Engineering, National Taiwan University of Science and Technology, The Ohio State University

Language: English

Topic: Microfluidic and Capillary Electrophoresis Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: bronze

Funders: National Science Council, Chung Yuan Christian University

OpenAlex ID: W2075724057

FWCI: 2.186

Cites: 14

Cited by: 28

Related to: 10