Year: 2013
Type: article
Study design: Clinical Trial
Abstract: OBJECTIVE: This study compared BMD relative to body weight following a ∼6-month weight loss program and a 1-year weight maintenance phase in premenopausal women and determined whether African American (AA) and European-American (EA) women's BMD respond similarly during weight loss. DESIGN AND METHODS: Premenopausal women (n = 115, 34 ± 5 years) were evaluated in an overweight state (BMI between 27 and 30 kg/m(2) ), following an 800 kcal/day diet/exercise program designed to reduce BMI<25 kg/m(2) , and 1-year following weight loss. RESULTS: BMD relative to body weight (Z-scores) increased after weight loss, but decreased during the 1-year weight maintenance phase. All 1-year follow-up BMD Z-scores were increased (except L1) compared to baseline measurements (P < 0.05). These sites included the hip neck (+0.088, P = 0.014), total hip (+0.099, P = 0.001), L2 (+0.127, P = 0.013), L3 (+0.135, P = 0.014), and L4 (+0.199, P = 0.002). AAs had significantly higher absolute BMD at all sites (P < 0.05) compared to EAs, but no time by race interactions were evident during weight loss (except in L3). CONCLUSION: These results may indicate that weight loss is safe with regard to bone health for overweight premenopausal women.
Source: Obesity
DOI: 10.1002/oby.20052
Institutions: University of Alabama, University of Alabama at Birmingham
Language: English
Subfield: Orthopedics and Sports Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G283777812, G3179975197, G410248719, Exercise Intensity, Metabolic Rate & Insulin Sensitivity, UAB Diabetes Research and Training Center, General Clinical Research Center, Long-term follow-up of postobese black and white women, UAB Obesity Training Program, UAB Nutrition Obesity Research Center (NORC)
OpenAlex ID: W2075997900