Work

Discovery of Herpes B Virus-Encoded MicroRNAs

Year: 2009

Type: article

Abstract: Herpes B virus (BV) naturally infects macaque monkeys and is a close relative of herpes simplex virus. BV can zoonotically infect humans to cause a rapidly ascending encephalitis with approximately 80% mortality. Therefore, BV is a serious danger to those who come into contact with these monkeys or their tissues and cells. MicroRNAs are regulators of gene expression, and there have been reports of virus-encoded microRNAs. We hypothesize that BV-encoded microRNAs are important for the regulation of viral and cellular genes. Herein, we report the discovery of three herpes B virus-encoded microRNAs.

Source: Journal of Virology

DOI: 10.1128/jvi.02419-08

Authors: Michael I. Besecker, Mallory E. Harden, Guanglin Li, Xiu-Jie Wang, Anthony Griffiths

Institutions: Texas Biomedical Research Institute, Chinese Academy of Sciences, State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology

Language: English

Topic: Herpesvirus Infections and Treatments

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Center for Research Resources