Work

MicroRNAs and HIV-1: Complex Interactions

Year: 2012

Type: review

Abstract: RNAi plays important roles in many biological processes, including cellular defense against viral infection. Components of the RNAi machinery are widely conserved in plants and animals. In mammals, microRNAs (miRNAs) represent an abundant class of cell encoded small noncoding RNAs that participate in RNAi-mediated gene silencing. Here, findings that HIV-1 replication in cells can be regulated by miRNAs and that HIV-1 infection of cells can alter cellular miRNA expression are reviewed. Lessons learned from and questions outstanding about the complex interactions between HIV-1 and cellular miRNAs are discussed.

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.r112.415448

Authors: Zachary Klase, Laurent Houzet, Kuan-Teh Jeang

Institutions: National Institutes of Health, National Institute of Allergy and Infectious Diseases

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,430