Work

Discovery of Potent and Selective Urea-Based ROCK Inhibitors and Their Effects on Intraocular Pressure in Rats

Year: 2010

Type: article

Abstract: A series of urea-based Rho kinase (ROCK) inhibitors were designed and evaluated. The discovered compounds had excellent enzyme and cellular potency, high kinase selectivity, high aqueous solubility, good porcine corneal penetration, and appropriate DMPK profiles for topical applications as antiglaucoma therapeutics.

Source: ACS Medicinal Chemistry Letters

DOI: 10.1021/ml1000382

Authors: Yan Yin, Michael D. Cameron, Li Lin, Susan Khan, Thomas Schröter, Wayne Grant, Jennifer Pocas, Yen Ting Chen, Stephan Schürer, Alok Pachori, Philip LoGrasso, Yangbo Feng

Institution: University of Miami

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2076270411

FWCI: 2.477

Cites: 19

Cited by: 45

Related to: 10