Work

Thrombotic thrombocytopenic purpura associated with HIV and visceral Kaposi's sarcoma treated with plasmapheresis and chemotherapy

Year: 1998

Type: article

Abstract: We present a case of a patient who is HIV positive and developed both thrombotic thrombocytopenia purpura and visceral Kaposi's sarcoma (KS) with hemorrhage. This case presents a difficult management problem in that the patient's bleeding originated from KS lesions and did not quickly abate with plasmapheresis therapy despite both clinical and laboratory improvement after 2–4 days. Chemotherapy was initiated on day 13 and the patient's condition improved markedly afterward. We believe the addition of chemotherapy to plasmapheresis hastened the improvement of our patient's thrombotic thrombocytopenic purpura (TTP) and KS-related bleeding. Therefore, under similar conditions, we recommend combining plasmapheresis and chemotherapy at the onset of therapy. Am. J. Hematol. 58:148–149, 1998. Published 1998 Wiley-Liss, Inc.1 This article is a U.S. Government work and, as such, is in the public domain in the United States of America.

Source: American Journal of Hematology

DOI: 10.1002/(sici)1096-8652(199806)58:2<148::aid-ajh12>3.0.co;2-7

Authors: Robert A. Avery, Troy M. Denunzio, Daniel B. Craig

Institution: United States Army

Language: English

Topic: Complement system in diseases

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,450