Work

Spatially selective photocoagulation of biological tissues: feasibility study utilizing cryogen spray cooling

Year: 1996

Type: article

Abstract: Successful laser treatment of selected dermatoses such as hemangiomas requires thermally induced damage to blood vessels while protecting the epidermis. We present and test a procedure in a rabbit liver tissue model that utilizes cryogen spray cooling during continuous Nd:YAG laser irradiation to induce deep photocoagulation necrosis while protecting superficial tissues from thermal injury. Gross and histologic observations are consistent with calculated thicknesses of protected and photocoagulated tissues and demonstrate the feasibility of inducing spatially selective photocoagulation when cryogen spray cooling is used in conjunction with laser irradiation. This procedure may be useful in the thermal treatment of some pathological conditions for which it is desired that deep photocoagulation be induced while protecting superficial tissues.

Source: Applied Optics

DOI: 10.1364/ao.35.003314

Authors: Bahman Anvari, B. Samuel Tanenbaum, Thomas E. Milner, Kimberly Tang, Lih-Huei Liaw, Ken Kalafus, Sol Kimel, J. Stuart Nelson

Institutions: University of California, Irvine, Beckman Laser Institute and Medical Clinic, Harvey Mudd College, Technion – Israel Institute of Technology

Language: English

Topic: Optical Imaging and Spectroscopy Techniques

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2076281106

FWCI: 2.317

Cites: 26

Cited by: 35

Related to: 10