Work

Not simply misshapen red cells: multimolecular and cellular events in sickle vaso-occlusion

Year: 2014

Type: article

Abstract: Thromboinflammatory diseases result from the interactions of vascular endothelial cells, inflammatory cells, and platelets with cellular adhesion molecules, plasma proteins, and lipids. Tipping the balance toward a prothrombotic, proinflammatory phenotype results from multicellular activation signals. In this issue of the JCI, Li et al. explore the regulation of heterotypic neutrophil-platelet contacts in response to TNF-α-induced venular inflammation with relevance to sickle cell disease (SCD).

Source: Journal of Clinical Investigation

DOI: 10.1172/jci75238

Authors: Gregory M. Vercellotti, John D. Belcher

Institution: University of Minnesota

Language: English

Topic: Hemoglobinopathies and Related Disorders

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: New York State Stem Cell Science, National Institutes of Health, National Heart, Lung, and Blood Institute