Work

Facile and Unified Approach to Skeletally Diverse, Privileged Scaffolds

Year: 2011

Type: article

Abstract: A novel strategy has been developed to generate a diverse array of privileged scaffolds from readily available tetrahydropyridine precursors that may be prepared by a multicomponent assembly process followed by a ring-closing metathesis. The functionality embedded in these key intermediates enables their facile elaboration into more complex structures of biological relevance by a variety of ring-forming processes and refunctionalizations.

Source: Organic Letters

DOI: 10.1021/ol200709h

Authors: James J. Sahn, Justin Y. Su, Stephen F. Martin

Institution: The University of Texas at Austin

Language: English

Topic: Synthetic Organic Chemistry Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: G150393960, Generating Diverse Pilot-Scale Libraries for Screening