Work

Trigocherrierin A, a Potent Inhibitor of Chikungunya Virus Replication

Year: 2014

Type: article

Abstract: Trigocherrierin A (1) and trigocherriolide E (2), two new daphnane diterpenoid orthoesters (DDOs), and six chlorinated analogues, trigocherrins A, B, F and trigocherriolides A-C, were isolated from the leaves of Trigonostemon cherrieri. Their structures were identified by mass spectrometry, extensive one- and two-dimensional NMR spectroscopy and through comparison with data reported in the literature. These compounds are potent and selective inhibitors of chikungunya virus (CHIKV) replication. Among the DDOs isolated, compound 1 exhibited the strongest anti-CHIKV activity (EC₅₀ = 0.6 ± 0.1 µM, SI = 71.7).

Source: Molecules

DOI: 10.3390/molecules19033617

Authors: Mélanie Bourjot, Pieter Leyssen, Johan Neyts, Vincent Dumontet, Marc Litaudon

Institutions: Rega Institute for Medical Research, KU Leuven, Centre National de la Recherche Scientifique, Institut de Chimie des Substances Naturelles

Language: English

Topic: Bioactive Natural Diterpenoids Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,258